The most frequent readings of the two kanjis are onore and nanji. It is unfortunate that you chose not to provide context but I shan't change my judgement unless different readings are suggested in the context either by furigana or okurigana.
Context is not necessary because it's more of a general question, whether theres a way to figure out the reading other than by experience.
Can you formulate some rough guidelines in which kind of context which reading is used ?
Anyhow the sentence that made me remember to ask about those 2 was: